Assistant Professor

B.Eng.(MedE) Medical Engineering Programme (First Hon.), The University of Hong Kong

Ph.D., The University of Hong Kong

Phone: 2831 5361
Email: jchanyk@hku.hk

ORCID: 0000-0002-1044-2668
 HKU Scholars Hub

Dr. Chan has a biomedical engineering background and dedicates himself to apply bioengineering technologies in the field of ophthalmology. His research interest lies in the design and testing of ophthalmic biomaterials, surgical tools and diagnostic tools, and the development of eye-on-a-chip microfluidic platforms for physiologically relevant studies in eye research. 

 

The current research focuses include:

(1) Eye-on-a-chip models for glaucoma-related and corneal scarring-related studies;

(2)Contact lens-based devices for theranostics applications; and 

(3)Microfluidic-based diagnostic tools for small volume sample analysis. 


Research Grants

  1. 2021 Seed Fund for Basic Research of the University of Hong Kong, Title: Fabrication of scaffoldless biological tissue templates using aqueous-three-phase-system (Principal Investigator)

  2. 2021 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: A surgical injector that rapidly and efficiently mix viscous fluids with precise small volume (Co-Investigator)

  3. 2020 Seed Fund for Translational and Applied Research of the University of Hong Kong, Title: A ‘Living’ Biological Bandage for Management of Ocular Surface Injuries (Principal Investigator)

  4. 2019 Start-up Fund from LKS Faculty of Medicine of the University of Hong Kong, Title: A microsurgical instrument installed with nano-structured oil-absorbent material for effective silicone oil removal in vitreoretinal surgery (Principal Investigator)

  5. 2019 Seed Fund for Basic Research for New Staff of the University of Hong Kong, Title: An “Artificial Eye” for studying pharmacokinetics of ophthalmic drugs and implants with drugs (Principal Investigator)

Teaching Grants:

  • 2021 HKU Teaching Development Grant, Title: New capstone experience in undergraduate-initiated biomedical research with interdisciplinary collaboration and student-patient interactions (Principal Investigator)

  • 2020 HKU Teaching Development Grant, Title: Introduction of Augmented Reality (AR) technologies to educate medical students the visual symptoms and progression of important vision-threatening diseases (Principal Investigator)

  • 2021 HKU Knowledge Exchange Impact Project Scheme, Title: Educating the elderly the visual symptoms of vision-threatening diseases through multisensory learning approach (Principal Investigator)


Publications

  1. Chan YK*, Laybourne J, Ng CO, Saha C, Yap HPY, Steel DH, Sandinha MT, Wong D*. A study of subretinal perfluorocarbon liquid (PFCL) droplets and the physics of their retention and removal. Acta Ophthalmologica 2021

  2. Kwok SS, Wong FSY, Shih KC, Chan YK, Bu Y, Chan TCY, Ng ALK, Lo ACY, Tong L, Yam GHF, Jhanji V. Lycium Barbarum Polysaccharide suppresses expression of fibrotic proteins in Primary human corneal fibroblasts. Journal of Clinical Medicine 2020;9(11):3572

  3. Chan YK*, Chen Y, Zhou L, Steel DH. Comment on “Fluid viscosity but not surface tension, determines the tamponade effect of intravitreal fluids in a novel in vitro eye model of retinal detachment” by A. Friehmann et al. (J. Mech. Behav. Biomed. Mater. 101 (2020) 103452). Journal of the Mechanical Behavior of Biomedical Materials 2020;113:104128

  4. Sandinha MT, Chan YK, Steel DH, Wong D. Spontaneous resolution of submacular perfluorocarbon liquids; Absorption or Evacuation? Retinal Cases & Brief Reports 2020 doi: 10.1097/ICB.0000000000001070.

  5. Poon SHL, Wong HL, Lo ACY, Jhanji V, Yuan H, Chen CF, Chan YK, Shih KC. A Systematic Review on Advances in Diagnostics for Herpes Simplex Keratitis: Current Concepts and Beyond. Survey of Ophthalmology 2020;S0039-6257(20)30138-7.

  6. Chen Y, Kearns V, Zhou L, ZHOU, Sandinha T, Lam WC, Steel DH*, Chan YK*. Silicone oil in vitreoretinal surgery: indications, complications, new developments and alternative long-term tamponade agents Acta Ophthalmologica, 2020

  7. Peng Z, Zhou L, Wong JKW, Chan YK*. Eye-on-a-chip (EOC) models and their role in the future of ophthalmic drug discovery. Expert Review of Ophthalmology 2020

  8. Nie L, Fu L, Chan YK, Fang A, Pan W. Combined Phacoemulsification with Goniosynechialysis under Ophthalmic Endoscope for Primary Angle Closure Glaucoma after Failed Trabeculectomy. Journal of Glaucoma 2020

  9. Wong HL, Vishal J, Lo ACY, Poon SHL, Bu Y, Chan YK, Shih KC. A Systematic Review on Cornea Epithelial-Stromal Homeostasis. Ophthalmic Research 2020

  10. Poon SHL, Wong HL, Bu Y, Lo ACY, Vishal J, Chan YK, Shih KC. A Systematic Review of Emerging Therapeutic Strategies in the Management of Chemical Injuries of the Ocular Surface. Eye and Contact Lens: Science & Clinical Practice 2020

  11. Fu L, Chan YK, Li J, Nie L, Li N, Pan W. Long Term Outcomes of Cataract Surgery in Severe and End Stage Glaucoma with Controlled IOP: A Retrospective Study. BMC Ophthalmology 2020;20;160.

  12. Chen Y, Zhou L, Chan YK*. Comment on “Safety of silicone oils as intraocular medical device: An in vitro cytotoxicity study” by M. R. Romano et al. (Exp. Eye Res. Vol 194, May 2020, 108018), Experimental Eye Research 2020;108032.

  13. Lu Y, Chan YK*, Lau LH, Wong D, Wong JKW, Shih K, Lai JSM, Shum HC*. Amphiphilic additives in silicone oil tamponade and emulsification: An eye-on-a-chip study, ACTA Ophthalmologica 2020;98:e232-e237.

  14. Fang A, Nie L, Wang P, Zheng J, Chan YK, Zhang Q, Liang Y, Jia Q. Silicone Tube Miniature Drainage Device Implanted under Scleral Flap for the Surgical Treatment of Glaucoma. Current Eye Research 2020; DOI: 10.1080/02713683.2019.1701687

  15. Qian Z, Chan YK, Wei L, Zheng B, Nie L, Pan W. Evaluation of two different anterior vitrectomies for fluid misdirection syndrome secondary to cataract surgery combined with goniosynechialysis. Journal of Ophthalmology 2020; 1934086.

  16. Bu Y, Shih KC, Kwok SS, Chan YK, Lo ACY, Chan TCY, Jhanji V, Tong L. Experimental Modelling of Cornea Wound Healing in Diabetes: Clinical Applications and Beyond. BMJ Open Diabetes Research & Care 2019;7:e000779.

  17. Lyu H, He Z, Chan YK, He X, Yu Y, Deng Y. Hierarchical ZnO Nanotube/Graphene Oxide Nanostructures Endow Pure Zn Implant with Synergistic Bactericidal Activity and Osteogenicity. Industrial & Engineering Chemistry Research 2019;58:19377-19385.

  18. Fu L, Kwok SS, Chan YK, Lai JSM, Pan W, Nie L, Shih KC. Therapeutic Strategies for Attenuation of Retinal Ganglion Cell Injury in Optic Neuropathies: Concepts in Translational Research and Therapeutic Implications. BioMed Research International 2019;2019:8397521.

  19. Nan L, Lai MYA, Tang MYH, Chan YK, Poon LLM, Shum HC. On-Demand Droplet Collection for Capturing Single Cells. Small 2019;1902889.

  20. Chan YK, Yan WH, Hung LT, Chao Y, Wu J, Shum HC. All-Aqueous Thin-Film-Flow-Induced Cell-Based Monolayers. ACS Applied Materials & Interfaces 2019;11:22869-22877. (Featured in Supplementary Cover).

  21. Wu J, Mak HK, Chan YK, Chen L, Kong C, Leung KS, Shum HC. An in vitro pressure model towards studying the response of primary retinal ganglion cells to elevated hydrostatic pressures.Scientific Reports 2019;9:9057.

  22. Lu Y, Chan YK*, Lau LH, Chao Y, Shih K, Lai JSM, Wong D, Shum HC*. Adhesion of silicone oil and emulsification: An in vitro assessment using a microfluidic device and “Eye-on-a-Chip”, ACTA Ophthalmologica 2019;97:313-318

  23. Fu L, Chan YK, Nie L, Dai Q, Qian Z, Shih K, Lai SMJ, Huang R, Pan W. Ciliochoroidal Detachment after Ahmed Glaucoma Valve Implantation: A Retrospective Study. BMC Ophthalmology 2019;19:46.

  24. Nie L, Pan W, Fang A, Li Z, Qian Z, Fu L, Chan YK. Combined Phacoemulsification and Goniosynechialysis under Endoscope for Chronic Primary Angle-closure Glaucoma. Journal of Ophthalmology 2018;2018:7.

  25. Lin F, Lo ACY, Chan YK, So KW, Wong IYH, Shih KC, Lai SM. Transcorneal Electrical Stimulation Inhibits Microglial Activation and Enhances Retinal Ganglion Cell Survival after Acute Ocular Hypertensive Injury. Translational Vision Science & Technology 2018;7:7.

  26. Nie L, Fang A, Pan W, Ye H, Chan YK, Fu L, Qu J. Prospective Study on Ex-PRESS Implantation Combined with Phacoemulsification in Primary Angle-closure Glaucoma Coexisting Cataract: 3-year Results. Current Eye Research2018;43:1045-1051.

  27. Stefansson E, Chan YK, Bek T, Hardarson SH, Wong D, Wilson DI. Laws of physics help explain capillary non-perfusion in diabetic retinopathy. Eye2018;32:210-212.

  28. Wong D, Chan YK, Bek T, Wilson DI, Stefansson E. Intraocular currents, Bernoulli's principle and non-drainage scleral buckling for rhegmatogenous retinal detachment. Eye2018;32:213-221.

  29. Chan YK, Cheng HC, Wu J, Tang YHM, Chan ST, Wong D, Shum HC. A perfluorobutylpentane (F4H5)-based solution for the removal of residual emulsified silicone oil. Acta Ophthalmologica2018, 96:e38-e45.

  30. Chan YK, Lu Y, Czanner G, et al. In vitro experiment to elucidate the mechanism of the ‘soft shell technique’ for preventing subretinal migration of perfluoro-octane. British Journal of Ophthalmology 2017;101:389-394.

  31. Yuan H, Ma Q, Song Y, Tang MYH, Chan YK, Shum HC. Phase-Separation-Induced Formation of Janus Droplets Based on Aqueous Two-Phase Systems. Macromolecular Chemistry and Physics 2017;218:1600422.

  32. Chan YK, Czanner G, Shum HC, Williams RL, Cheung N, Wong D. Towards better characterisation and quantification of emulsification of silicone oil in vitro. Acta Ophthalmologica 2017;95:e385-e392.

  33. Song Y, Chan YK, Ma Q, Liu Z, Shum HC. All-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules. ACS Applied Materials & Interfaces. 2015;7:13925-13933.

  34. Chan YK, Sy KHS, Wong CY, Man PKE, Wong D, Shum HC. In vitro Modeling of Emulsification of Silicone Oil as Intraocular Tamponade Using Microengineered Eye-on-a-Chip. Investigative Ophthalmology & Visual Science 2015;56:3314-3319.

  35. Caramoy A, Kearns VR, Chan YK, et al. Development of emulsification resistant heavier-than-water tamponades using high molecular weight silicone oil polymers. Journal of Biomaterials Applications. 2015;30:212-220.

  36. Chan YK, Wong D, Yeung HK, Man PK, Shum HC. A Low-molecular-weight-oil Cleaner For Removal Of Leftover Silicone Oil Intraocular Tamponade. Investigative Ophthalmology & Visual Science 2015;56:1014-1022.

  37. Chan YK, Cheung N, Chan WSC, Wong D. Quantifying silicone oil emulsification in patients: are we only seeing the tip of the iceberg? Graefe's Arch Clin Exp Ophthalmol 2015;253:1671-1675.

  38. Chan YK, Williams RL, Wong D. Flow Behavior of Heavy Silicone Oil During Eye Movements. Investigative Ophthalmology & Visual Science 2014;55:8453-8457.

  39. Chan YK, Cheung N, Wong D. Factors Influencing the Shear Rate Acting on Silicone Oil to Cause Silicone Oil Emulsification. Investigative Ophthalmology & Visual Science 2014;55:7451-7456.

  40. Chan YK, Ng CO, Knox PC, Garvey MJ, Williams RL, Wong D. Emulsification of Silicone Oil and Eye Movements. Investigative Ophthalmology & Visual Science 2011;52:9721-9727.

* Corresponding Author