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Principal Investigator:

  Dr. Kendrick Co Shih, Clinical Associate Professor of Practice

Enrolled Postgraduate Students:

  • Ms Stephanie Hiu-Ling Poon, Master of Research (Medicine) candidate

  • Mr William Ho-Lam Wong, Master of Research (Medicine) candidate

  • Mr Allan Chu, Master of Research (Medicine) candidate

  • Ms Noel Cheong, Master of Research (Medicine) candidate

Graduated Postgraduate Students

  • Dr. Lin Fu, Doctor of Philosophy 2016

  • Dr Sum Sum Kwok, Master of Research (Medicine) 2021

  • Dr. Yashan Bu, Doctor of Philosophy 2022

Research Staff:

  • Ms Riko Man-Man Kung, Senior Research Assistant

  • Dr. Yashan Bu, Research Assistant

  • Ms Tricia Po-Yin Wu, Research Assistant

  • Mr Raymond Yip, Research Assistant

Local and International Collaborators:

  • Dr. Sharon She-Wan Chow, Specialist in Ophthalmology, Hong Kong 

  • Dr. Alex Lap-Ki Ng, Specialist in Ophthalmology, Hong Kong

  • Dr. Tommy Chun-Yan Chan, Specialist in Ophthalmology, Hong Kong

  • Prof. Louis Tong,  Clinical Professor and Senior Consultant, Duke-NUS Medical School, Singapore

  • Prof. Vishal Jhanji, Clinical Professor, Department of Ophthalmology, University of Pittsburgh Medical School, USA


The goals of our research group are to understand corneal and ocular surface disease from a basic science and translational research point of view, with a focus on the following:

  • Dry eye disease epidemiology and associations with systemic disease

  • Novel therapies in dry eye disease and corneal neuropathic pain

  • The interaction between ocular surface immunity, gut microflora and corneal epithelial wound healing in health and disease

  • The molecular basis for corneal remodelling and prevention of stromal fibrosis after injury

Selected Group Publications (4 per research area, in descending order of impact factor)

Ocular Surface Inflammation

  • Hui P.Y., Cheung M.C., Perera R.A.P.M., Ng K.C., Bui H.T., Ho C.W.J., Ng M.M.T., Kuok I.T., Shih K.C., Tsao G.S.W., Poon L.M.L., Peiris J.S.M., Nicholls J.M. and Chan M.C.W., Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures, The Lancet Respiratory Medicine. 2020.

  • Poon SH, Wong WH, Lo AC, Yuan H, Chen CF, Jhanji V, Chan YK, Shih KC. A Systematic Review on Advances in Diagnostics for Herpes Simplex Keratitis. Surv Ophthalmol. 2020

  • Shih K.C., Lun C.N., Jhanji V., Thong B.Y. and Tong L., Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome, Journal of Inflammation. United Kingdom, 2017

  • Chow, L.L.W., Shih, K.C., Chan, J.C.Y. et al. Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study. BMC Ophthalmol. 2017

Cornea Wound Healing

  • Kwok SS, Wong F -Y, Shih KC, Chan Y-K, Bu Y, Chan T -Y, Ng A -K, Lo A -Y, Tong L, Yam G -F, Jhanji V. Lycium barbarum Polysaccharide Suppresses Expression of Fibrotic Proteins in Primary Human Corneal Fibroblasts. Journal of Clinical Medicine. 2020

  • Bu Y., Shih K.C., Kwok S.S., Chan Y.K., Lo A.C.Y., Chan T.C.Y., Jhanji V. and Tong L., Experimental modelling of cornea wound healing in diabetes: clinical applications and beyond, BMJ Open Diabetes Research & Care. 2019

  • Wong H.L., Bu Y., Chan Y.K. and Shih K.C., Lycium barbarum polysaccharide promotes corneal Re-epithelialization after alkaline injury, Experimental Eye Research. 2022, 109151. 

  • Wong HL, Hung LT, Kwok SS, Bu Y, Lin Y, Shum HC, Wang H, Lo ACY, Yam GHF, Jhanji V, Shih KC, Chan YK, The anti-scarring role of Lycium barbarum polysaccharide on cornea epithelial-stromal injury, Experimental Eye Research. 2021


Dry Eye Syndrome

  • Shih K.C., Lam K.S.L. and Tong L., A systematic review on the impact of diabetes mellitus on the ocular surface, Nutrition & Diabetes. 2017

  • Chan T.C.Y., Wan K.H., Shih K.C. and Jhanji V., Advances in dry eye imaging: the present and beyond, British Journal of Ophthalmology. 2017

  • Ma A., Mak M.S., Shih K.C., Tsui C.K., Cheung R.K., Lee S.H., Leung H., Leung J.N., Leung J.T., Van-Boswell M.Z., Wong M.T., Ng L.K.A., Lee C.H.P., Jhanji V. and Tong L., Association of long-term glycaemic control on tear break up times and dry eye symptoms in Chinese patients with type 2 diabetes, Clinical & Experimental Ophthalmology. 2018.

  • Chuang J., Shih K.C., Chan T.C.Y., Wan K.H., Jhanji V. and Tong L., Preoperative optimization of ocular surface disease before cataract surgery, Journal of Cataract and Refractive Surgery. Elsevier, 2018, 43 (11), 1596 –1607.

Funding (As Principal Investigator)

  • 2020 Li Shu Pui Medical Foundation Fellowship. Title: Development and validation of an AI-assisted clinical decision making system for laser refractive surgery. HKD 585,630

  • 2019 Health and Medical Research Fund, Department of Health, HKSAR. Title: Evaluation of the accuracy of diagnostic and management decision by teleophthalmology in comparison with face-to face consultation. HKD 613,848

  • 2019 SK Yee Medical Foundation Grant, HKSAR Title: Intense pulsed light therapy in the management of moderate to severe ocular surface disease. HKD 400,000

  • 2018 Timothy KC Liu Memorial Fund Award, College of Ophthalmologists of Hong Kong/ Hong Kong Ophthalmological Society, HKSAR. Title: Lycium Barbarum Polysaccharide Solution as a Novel Therapuetic Agent in the Prevention of Cornea Scarring. HKD 30,000

  • 2017 SK Yee Medical Foundation Grant, HKSAR Title: The introduction of Descemet’s membrane endothelial keratoplasty surgery for public patients and skill transfer to cornea surgeons in Hong Kong. HKD 278,600

  • 2015 SK Yee Medical Foundation Grant, HKSAR. Title: To Introduce Boston Keratoprosthesis for the Treatment of Corneal Blindness in Queen Mary Hospital. HKD 249,460

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