Principal Investigators:

  Dr. Kendrick Co Shih, Clinical Assistant Professor

  Dr. Sharon Chow, Clinical Assistant Professor

Graduate Students:

  • Ms Yashan Bu, PhD Candidate

  • Ms Sum Sum Kwok, Master of Research (Medicine) candidate

  • Ms Stephanie Hiu-Ling Poon, Master of Research (Medicine) candidate

  • Mr William Ho-Lam Wong, Master of Research (Medicine) candidate

  • Mr Allan Chu, Master of Research (Medicine) candidate

  • Ms Noel Cheong, Master of Research (Medicine) candidate

Local and International Collaborators:

  • Dr. Alex Lap-Ki Ng, Specialist in Ophthalmology, Hong Kong

  • Dr. Tommy Chun-Yan Chan, Specialist in Ophthalmology, Hong Kong

  • Prof. Louis Tong,  Clinical Professor and Senior Consultant, Duke-NUS Medical School, Singapore

  • Prof. Vishal Jhanji, Clinical Professor, Department of Ophthalmology, University of Pittsburgh Medical School, USA

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The goals of our research group are to understand corneal and ocular surface disease from a basic science and translational research point of view, with a focus on the following:

  • Dry eye disease epidemiology and associations with systemic disease

  • Novel therapies in dry eye disease and corneal neuropathic pain

  • The interaction between ocular surface immunity, gut microflora and corneal epithelial wound healing in health and disease

  • The molecular basis for corneal remodelling and prevention of stromal fibrosis after injury

Selected Group Publications (4 per research area, in descending order of impact factor)

Ocular Surface Inflammation

  • Hui P.Y., Cheung M.C., Perera R.A.P.M., Ng K.C., Bui H.T., Ho C.W.J., Ng M.M.T., Kuok I.T., Shih K.C., Tsao G.S.W., Poon L.M.L., Peiris J.S.M., Nicholls J.M. and Chan M.C.W., Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures, The Lancet Respiratory Medicine. 2020.

  • Poon SH, Wong WH, Lo AC, Yuan H, Chen CF, Jhanji V, Chan YK, Shih KC. A Systematic Review on Advances in Diagnostics for Herpes Simplex Keratitis. Surv Ophthalmol. 2020

  • Shih K.C., Lun C.N., Jhanji V., Thong B.Y. and Tong L., Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome, Journal of Inflammation. United Kingdom, 2017

  • Chow, L.L.W., Shih, K.C., Chan, J.C.Y. et al. Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study. BMC Ophthalmol. 2017

Cornea Wound Healing

  • Kwok SS, Wong F -Y, Shih KC, Chan Y-K, Bu Y, Chan T -Y, Ng A -K, Lo A -Y, Tong L, Yam G -F, Jhanji V. Lycium barbarum Polysaccharide Suppresses Expression of Fibrotic Proteins in Primary Human Corneal Fibroblasts. Journal of Clinical Medicine. 2020

  • Bu Y., Shih K.C., Kwok S.S., Chan Y.K., Lo A.C.Y., Chan T.C.Y., Jhanji V. and Tong L., Experimental modelling of cornea wound healing in diabetes: clinical applications and beyond, BMJ Open Diabetes Research & Care. 2019

  • Wong H.L., PoonH.L., BUY., Lo A.C.Y., Jhanji V., Chan Y.K. and Shih K.C., A Systematic Review on Cornea Epithelial-Stromal Homeostasis, Ophthalmic Research. 2020

  • Chow SSW, Chan TCY, Wong IYH, Fan MCY, Lai JSM, Ng ALK. Early epithelial complications of accelerated trans-epithelial corneal crosslinking in treatment of keratoconus: a case series. Int Ophthalmol. 2018

Dry Eye Syndrome

  • Shih K.C., Lam K.S.L. and Tong L., A systematic review on the impact of diabetes mellitus on the ocular surface, Nutrition & Diabetes. 2017

  • Chan T.C.Y., Wan K.H., Shih K.C. and Jhanji V., Advances in dry eye imaging: the present and beyond, British Journal of Ophthalmology. 2017

  • Ma A., Mak M.S., Shih K.C., Tsui C.K., Cheung R.K., Lee S.H., Leung H., Leung J.N., Leung J.T., Van-Boswell M.Z., Wong M.T., Ng L.K.A., Lee C.H.P., Jhanji V. and Tong L., Association of long-term glycaemic control on tear break up times and dry eye symptoms in Chinese patients with type 2 diabetes, Clinical & Experimental Ophthalmology. 2018.

  • Chan TCY, Chow SSW, Wan KHN, Yuen HKL. Update on the association between dry eye disease and meibomian gland dysfunction. Hong Kong Med J. 2019

Funding (As Principal Investigator)

  • 2020 Li Shu Pui Medical Foundation Fellowship. Title: Development and validation of an AI-assisted clinical decision making system for laser refractive surgery. HKD 585,630

  • 2020 Timothy KC Liu Memorial Fund Award, Hong Kong Ophthalmological Society: A randomized controlled trial on the therapeutic efficacy of Intense Pulsed Light in treating Prostaglandin Analogue related Dry Eye Disease. HKD $9634

  • 2019 Health and Medical Research Fund, Department of Health, HKSAR. Title: Evaluation of the accuracy of diagnostic and management decision by teleophthalmology in comparison with face-to face consultation. HKD 613,848

  • 2019 SK Yee Medical Foundation Grant, HKSAR Title: Intense pulsed light therapy in the management of moderate to severe ocular surface disease. HKD 400,000

  • 2018 Timothy KC Liu Memorial Fund Award, College of Ophthalmologists of Hong Kong/ Hong Kong Ophthalmological Society, HKSAR. Title: Lycium Barbarum Polysaccharide Solution as a Novel Therapuetic Agent in the Prevention of Cornea Scarring. HKD 30,000

  • 2017 SK Yee Medical Foundation Grant, HKSAR Title: The introduction of Descemet’s membrane endothelial keratoplasty surgery for public patients and skill transfer to cornea surgeons in Hong Kong. HKD 278,600

  • 2015 SK Yee Medical Foundation Grant, HKSAR. Title: To Introduce Boston Keratoprosthesis for the Treatment of Corneal Blindness in Queen Mary Hospital. HKD 249,460

Featured in Press

 

How Susceptible is the Conjunctiva to COVID-19?

https://www.reviewofophthalmology.com/article/how-susceptible-is-the-conjunctiva-to-covid19

 

Dry eye related to smartphone addiction in university students

https://www.healio.com/news/ophthalmology/20180926/dry-eye-related-to-smartphone-addiction-in-university-students

 

Common Infections In The Context Of An Acute Red Eye: A Primary Care Physician’s Guide

https://www.thkma.org/members/selfstudy/202102/CMEBulletin.pdf

 

醫療:公立醫院引入幹細胞移植手術 料助修復眼角膜

https://news.tvb.com/story/4ff67eb96db28cc90f000001/5b968e35e60383864be93fb0

 

Dr 東:化學品濺入眼恐致盲 羊膜移植保視力

https://www.youtube.com/watch?v=fZwZAizqrkQ

最強生命線- 容易受傷的眼睛

https://news.tvb.com/programmes/vitallifeline/5cbd8a25e60383f23381a103

Columns in Newspaper

 

醫健寶庫:兩大新療法 治眼部化學損傷

https://orientaldaily.on.cc/cnt/news/20180414/00176_102.html

 

醫理 - 港大李嘉誠醫學院 瞼板腺囊腫

http://archive.am730.com.hk/column-227817

 

醫健寶庫:視網膜病變 反映血管欠佳

https://orientaldaily.on.cc/cnt/news/20151219/00176_103.html

 

醫健寶庫:眼睛燒灼感 紅眼症病徵

https://orientaldaily.on.cc/cnt/news/20150808/00176_103.html

 

醫理 - 港大李嘉誠醫學院 預防近視加深

http://archive.am730.com.hk/column-229707

 

醫理 - 港大李嘉誠醫學院 角膜緣幹細胞缺乏症

http://archive.am730.com.hk/column-228942

視必有因: 香港眼科學會 - 彩光治療、導溫脈動療法 解決「蒸發性乾眼症」

https://www.am730.com.hk/column-252157