Uncovering the trajectories of axonal fiber bundles to augment the diagnostic precision to detect retinal nerve fiber layer defects in glaucoma

Reliable detection of retinal nerve fiber layer (RNFL) defects is challenging in clinical practice. We developed RNFL Optical Texture Analysis (ROTA) to unveil the trajectories of individual axonal fiber bundles and discern RNFL defects in glaucoma with high sensitivity and specificity.